Drug interactions
Hydrocodone + Idelalisib
Severity: Major
Hydrocodone and Idelalisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and can substantially raise hydrocodone concentrations, increasing the risk of respiratory depression and prolonged sedation.
What this interaction means in plain words
Hydrocodone and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrocodone belongs to Musculoskeletal; Idelalisib belongs to Oncology.
Why it happens
Strong inhibition of CYP3A4-mediated metabolism of hydrocodone.
What to do
Use the lowest effective hydrocodone dose with close monitoring for respiratory depression and sedation. Consider an alternative opioid less reliant on CYP3A4.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Hydrocodone with Idelalisib?
MediHelp rates the interaction as major. Hydrocodone and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A4 inhibitor and can substantially raise hydrocodone concentrations, increasing the risk of respiratory depression and prolonged sedation.
How serious is the interaction between Hydrocodone and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydrocodone dose with close monitoring for respiratory depression and sedation. Consider an alternative opioid less reliant on CYP3A4.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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