Drug interactions
Hydrocodone + Nevirapine
Severity: Moderate
Hydrocodone and Nevirapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and can lower hydrocodone concentrations, potentially reducing analgesia or precipitating withdrawal. If nevirapine is stopped, hydrocodone levels may rise and cause toxicity including respiratory depression.
What this interaction means in plain words
Hydrocodone and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Nevirapine belongs to Anti Virals.
Why it happens
CYP3A4 induction by nevirapine increases hydrocodone metabolism.
What to do
Monitor pain control and withdrawal symptoms and titrate hydrocodone as needed. When nevirapine is discontinued, reduce the hydrocodone dose and watch for sedation and respiratory depression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Hydrocodone with Nevirapine?
MediHelp rates the interaction as moderate. Hydrocodone and Nevirapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nevirapine induces CYP3A4 and can lower hydrocodone concentrations, potentially reducing analgesia or precipitating withdrawal. If nevirapine is stopped, hydrocodone levels may rise and cause toxicity including respiratory depression.
How serious is the interaction between Hydrocodone and Nevirapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal symptoms and titrate hydrocodone as needed. When nevirapine is discontinued, reduce the hydrocodone dose and watch for sedation and respiratory depression.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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