Drug interactions
Hydrocodone + Pegvisomant
Severity: Moderate
Hydrocodone and Pegvisomant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegvisomant labeling notes that patients on opioids may need higher pegvisomant doses to control IGF-I. The effect is poorly characterized and may weaken disease control in acromegaly.
What this interaction means in plain words
Hydrocodone and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Pegvisomant belongs to Endocrine.
Why it happens
Mechanism is not established.
What to do
Monitor serum IGF-I after starting or stopping opioids and titrate pegvisomant accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Pegvisomant
- Alogliptin-metformin + Pegvisomant Moderate
- Alogliptin-pioglitazone + Pegvisomant Moderate
- Chlorpropamide + Pegvisomant Moderate
- Codeine + Pegvisomant Moderate
- Dapagliflozin-metformin + Pegvisomant Moderate
- Ertugliflozin-sitagliptin + Pegvisomant Moderate
Frequently asked questions
Can I take Hydrocodone with Pegvisomant?
MediHelp rates the interaction as moderate. Hydrocodone and Pegvisomant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegvisomant labeling notes that patients on opioids may need higher pegvisomant doses to control IGF-I. The effect is poorly characterized and may weaken disease control in acromegaly.
How serious is the interaction between Hydrocodone and Pegvisomant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum IGF-I after starting or stopping opioids and titrate pegvisomant accordingly.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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