Drug interactions
Hydrocodone + Rizatriptan
Severity: Moderate
Hydrocodone and Rizatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and triptans both influence serotonergic signaling, and combined use has been linked to serotonin syndrome in case reports. The absolute risk appears low.
What this interaction means in plain words
Hydrocodone and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects.
What to do
Educate the patient on serotonin syndrome symptoms and monitor during initiation and dose changes. Discontinue one agent if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
Frequently asked questions
Can I take Hydrocodone with Rizatriptan?
MediHelp rates the interaction as moderate. Hydrocodone and Rizatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids and triptans both influence serotonergic signaling, and combined use has been linked to serotonin syndrome in case reports. The absolute risk appears low.
How serious is the interaction between Hydrocodone and Rizatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Educate the patient on serotonin syndrome symptoms and monitor during initiation and dose changes. Discontinue one agent if symptoms occur.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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