Drug interactions
Hydrocodone + Rucaparib
Severity: Minor
Hydrocodone and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib is a weak CYP3A inhibitor that may modestly raise hydrocodone concentrations. The clinical effect is generally small but could increase opioid adverse effects.
What this interaction means in plain words
Hydrocodone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hydrocodone belongs to Musculoskeletal; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 slightly reduces hydrocodone metabolism.
What to do
Monitor for increased sedation or respiratory depression after starting rucaparib and lower the hydrocodone dose if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Hydrocodone with Rucaparib?
MediHelp rates the interaction as minor. Hydrocodone and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib is a weak CYP3A inhibitor that may modestly raise hydrocodone concentrations. The clinical effect is generally small but could increase opioid adverse effects.
How serious is the interaction between Hydrocodone and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation or respiratory depression after starting rucaparib and lower the hydrocodone dose if symptoms occur.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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