Drug interactions
Hydrocodone + Sevoflurane
Severity: Major
Hydrocodone and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and volatile anesthetics produce additive CNS and respiratory depression and can cause hypotension. Perioperative use is routine but needs anesthetic dose adjustment.
What this interaction means in plain words
Hydrocodone and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydrocodone belongs to Musculoskeletal; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS and respiratory depression from mu-opioid agonism and general anesthetic action.
What to do
Use only under anesthetic supervision with reduced anesthetic and opioid doses as needed. Monitor ventilation, oxygenation, and blood pressure continuously, including postoperatively.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Sevoflurane
Frequently asked questions
Can I take Hydrocodone with Sevoflurane?
MediHelp rates the interaction as major. Hydrocodone and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and volatile anesthetics produce additive CNS and respiratory depression and can cause hypotension. Perioperative use is routine but needs anesthetic dose adjustment.
How serious is the interaction between Hydrocodone and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only under anesthetic supervision with reduced anesthetic and opioid doses as needed. Monitor ventilation, oxygenation, and blood pressure continuously, including postoperatively.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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