Drug interactions
Hydrocodone + Stiripentol
Severity: Moderate
Hydrocodone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol affects CYP3A4 in both directions and has sedative effects, so hydrocodone exposure may change unpredictably while CNS depression is additive. This can lead to oversedation or reduced analgesia.
What this interaction means in plain words
Hydrocodone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction plus additive CNS depression.
What to do
Monitor sedation, respiratory status, and pain control, and titrate hydrocodone to response. Advise avoiding alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Hydrocodone with Stiripentol?
MediHelp rates the interaction as moderate. Hydrocodone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol affects CYP3A4 in both directions and has sedative effects, so hydrocodone exposure may change unpredictably while CNS depression is additive. This can lead to oversedation or reduced analgesia.
How serious is the interaction between Hydrocodone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, respiratory status, and pain control, and titrate hydrocodone to response. Advise avoiding alcohol.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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