Drug interactions
Hydrocodone + Trimipramine
Severity: Moderate
Hydrocodone and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a sedating tricyclic, and combined use with hydrocodone may increase CNS depression and, less commonly, serotonin syndrome risk. Anticholinergic effects may also be additive.
What this interaction means in plain words
Hydrocodone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydrocodone belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and serotonergic effects, with possible CYP2D6 inhibition.
What to do
Monitor for sedation, respiratory depression and serotonin toxicity. Start at low doses and titrate carefully.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Hydrocodone with Trimipramine?
MediHelp rates the interaction as moderate. Hydrocodone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a sedating tricyclic, and combined use with hydrocodone may increase CNS depression and, less commonly, serotonin syndrome risk. Anticholinergic effects may also be additive.
How serious is the interaction between Hydrocodone and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and serotonin toxicity. Start at low doses and titrate carefully.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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