Drug interactions
Hydromorphone + Lurasidone
Severity: Moderate
Hydromorphone and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is a sedating atypical antipsychotic that may add to the CNS depressant effects of opioids. Drowsiness, dizziness and orthostatic hypotension can be more pronounced when combined with hydromorphone.
What this interaction means in plain words
Hydromorphone and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic antihistaminic and alpha-adrenergic blockade.
What to do
Monitor sedation and blood pressure when starting or increasing either drug. Reduce doses if excess drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Hydromorphone with Lurasidone?
MediHelp rates the interaction as moderate. Hydromorphone and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is a sedating atypical antipsychotic that may add to the CNS depressant effects of opioids. Drowsiness, dizziness and orthostatic hypotension can be more pronounced when combined with hydromorphone.
How serious is the interaction between Hydromorphone and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure when starting or increasing either drug. Reduce doses if excess drowsiness occurs.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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