Drug interactions
Hydromorphone + Paliperidone
Severity: Moderate
Hydromorphone and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can cause somnolence and orthostatic hypotension. Together with hydromorphone these effects may be additive, raising the risk of sedation, dizziness and falls.
What this interaction means in plain words
Hydromorphone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Monitor for sedation and orthostatic blood pressure changes, especially after dose increases. Adjust doses downward if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Hydromorphone with Paliperidone?
MediHelp rates the interaction as moderate. Hydromorphone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can cause somnolence and orthostatic hypotension. Together with hydromorphone these effects may be additive, raising the risk of sedation, dizziness and falls.
How serious is the interaction between Hydromorphone and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic blood pressure changes, especially after dose increases. Adjust doses downward if excessive drowsiness occurs.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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