Drug interactions
Hydromorphone + Selinexor
Severity: Moderate
Hydromorphone and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, fatigue, and confusion. Hydromorphone adds sedation and cognitive impairment, which may worsen falls and neurologic toxicity.
What this interaction means in plain words
Hydromorphone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydromorphone belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive CNS adverse effects; no pharmacokinetic interaction is established.
What to do
Monitor for dizziness, confusion and sedation, and counsel patients on fall risk. Reduce the opioid dose or adjust selinexor if neurologic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Hydromorphone with Selinexor?
MediHelp rates the interaction as moderate. Hydromorphone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, fatigue, and confusion. Hydromorphone adds sedation and cognitive impairment, which may worsen falls and neurologic toxicity.
How serious is the interaction between Hydromorphone and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dizziness, confusion and sedation, and counsel patients on fall risk. Reduce the opioid dose or adjust selinexor if neurologic symptoms develop.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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