Drug interactions
Hydroxycarbamide + Mycophenolate mofetil
Severity: Moderate
Hydroxycarbamide and Mycophenolate mofetil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow and immune function, so combining them increases the risk of cytopenias and infection. The interaction is mainly additive.
What this interaction means in plain words
Hydroxycarbamide and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxycarbamide belongs to Oncology; Mycophenolate mofetil belongs to Miscellaneous.
Why it happens
Additive myelosuppressive and immunosuppressive effects.
What to do
Monitor complete blood counts regularly and watch for infection. Reduce the dose of either drug if neutropenia or other cytopenias occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mycophenolate mofetil
- Adenovirus types 4 and 7 live + Mycophenolate mofetil Contraindicated
- Bcg vaccine live + Mycophenolate mofetil Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Mycophenolate mofetil Contraindicated
- Measles mumps and rubella vaccine live + Mycophenolate mofetil Contraindicated
- Measles mumps rubella and varicella vaccine live + Mycophenolate mofetil Contraindicated
- Measles vaccine + Mycophenolate mofetil Contraindicated
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Hydroxycarbamide with Mycophenolate mofetil?
MediHelp rates the interaction as moderate. Hydroxycarbamide and Mycophenolate mofetil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow and immune function, so combining them increases the risk of cytopenias and infection. The interaction is mainly additive.
How serious is the interaction between Hydroxycarbamide and Mycophenolate mofetil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and watch for infection. Reduce the dose of either drug if neutropenia or other cytopenias occur.
What other medicines interact with Mycophenolate mofetil?
MediHelp also lists interactions of Mycophenolate mofetil with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Mycophenolate mofetil page.
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