Drug interactions
Hydroxychloroquine + Quetiapine
Severity: Major
Hydroxychloroquine and Quetiapine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QT interval, so combined use may increase the risk of torsades de pointes. Patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs are at higher risk.
What this interaction means in plain words
Hydroxychloroquine and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxychloroquine belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Use an antipsychotic with less QT effect if feasible. Otherwise check a baseline ECG, follow the QTc and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Hydroxychloroquine with Quetiapine?
MediHelp rates the interaction as major. Hydroxychloroquine and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QT interval, so combined use may increase the risk of torsades de pointes. Patients with cardiac disease, electrolyte disturbance or other QT-prolonging drugs are at higher risk.
How serious is the interaction between Hydroxychloroquine and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antipsychotic with less QT effect if feasible. Otherwise check a baseline ECG, follow the QTc and correct potassium and magnesium.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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