Drug interactions
Hydroxychloroquine + Quizartinib
Severity: Major
Hydroxychloroquine and Quizartinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quizartinib causes dose-related QT prolongation and has a boxed warning for torsades de pointes. Hydroxychloroquine adds further QT prolongation, raising arrhythmia risk. Patients with acute myeloid leukemia often have electrolyte disturbances that increase this risk.
What this interaction means in plain words
Hydroxychloroquine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxychloroquine belongs to Musculoskeletal; Quizartinib belongs to Oncology.
Why it happens
Additive QT interval prolongation from both agents.
What to do
Avoid the combination if possible; otherwise monitor ECG frequently and keep potassium and magnesium normal. Reduce the quizartinib dose or hold it if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Quizartinib
- Quizartinib + Thioridazine Contraindicated
- Quizartinib + Ziprasidone Contraindicated
- Alfuzosin + Quizartinib Major
- Amiodarone + Quizartinib Major
- Amitriptyline + Quizartinib Major
- Amobarbital + Quizartinib Major
Frequently asked questions
Can I take Hydroxychloroquine with Quizartinib?
MediHelp rates the interaction as major. Hydroxychloroquine and Quizartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quizartinib causes dose-related QT prolongation and has a boxed warning for torsades de pointes. Hydroxychloroquine adds further QT prolongation, raising arrhythmia risk. Patients with acute myeloid leukemia often have electrolyte disturbances that increase this risk.
How serious is the interaction between Hydroxychloroquine and Quizartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor ECG frequently and keep potassium and magnesium normal. Reduce the quizartinib dose or hold it if QTc rises significantly.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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