Drug interactions
Hydroxychloroquine + Sertraline
Severity: Moderate
Hydroxychloroquine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline has a small QT effect and hydroxychloroquine prolongs the QT interval, so combined use may have an additive effect. The overall risk is generally modest but greater in patients with other risk factors.
What this interaction means in plain words
Hydroxychloroquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check an ECG at baseline in patients with cardiac risk factors and monitor the QTc. Correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Sertraline?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline has a small QT effect and hydroxychloroquine prolongs the QT interval, so combined use may have an additive effect. The overall risk is generally modest but greater in patients with other risk factors.
How serious is the interaction between Hydroxychloroquine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check an ECG at baseline in patients with cardiac risk factors and monitor the QTc. Correct potassium and magnesium.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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