Drug interactions
Hydroxychloroquine + Tetrabenazine
Severity: Moderate
Hydroxychloroquine and Tetrabenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tetrabenazine causes a small dose-related QT prolongation, and hydroxychloroquine adds to this. The combination increases the risk of arrhythmia, especially in those with congenital long QT or electrolyte disturbances.
What this interaction means in plain words
Hydroxychloroquine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through pharmacodynamic effects.
What to do
Obtain a baseline ECG and monitor QTc; avoid in patients with long QT syndrome or arrhythmia history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Tetrabenazine?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Tetrabenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tetrabenazine causes a small dose-related QT prolongation, and hydroxychloroquine adds to this. The combination increases the risk of arrhythmia, especially in those with congenital long QT or electrolyte disturbances.
How serious is the interaction between Hydroxychloroquine and Tetrabenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc; avoid in patients with long QT syndrome or arrhythmia history.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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