Drug interactions
Hydroxychloroquine + Vardenafil
Severity: Moderate
Hydroxychloroquine and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxychloroquine can prolong the QT interval and vardenafil has a modest QT effect, so combined use may increase the risk of ventricular arrhythmia. The concern is greatest in patients with cardiac disease, electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Hydroxychloroquine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Vardenafil belongs to Genitourinary.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Check a baseline ECG and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with congenital long QT syndrome or several other QT-prolonging drugs, and monitor the QTc if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Vardenafil?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxychloroquine can prolong the QT interval and vardenafil has a modest QT effect, so combined use may increase the risk of ventricular arrhythmia. The concern is greatest in patients with cardiac disease, electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Hydroxychloroquine and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and correct hypokalemia and hypomagnesemia. Avoid the combination in patients with congenital long QT syndrome or several other QT-prolonging drugs, and monitor the QTc if used.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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