Drug interactions
Hydroxychloroquine + Voclosporin
Severity: Moderate
Hydroxychloroquine and Voclosporin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin can prolong the QTc interval at supratherapeutic exposures, and hydroxychloroquine also prolongs QTc. Combined use may add to the risk of torsades de pointes, particularly in patients with kidney disease or electrolyte abnormalities who are often treated with both.
What this interaction means in plain words
Hydroxychloroquine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxychloroquine belongs to Musculoskeletal; Voclosporin belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during co-therapy. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Voclosporin?
MediHelp rates the interaction as moderate. Hydroxychloroquine and Voclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voclosporin can prolong the QTc interval at supratherapeutic exposures, and hydroxychloroquine also prolongs QTc. Combined use may add to the risk of torsades de pointes, particularly in patients with kidney disease or electrolyte abnormalities who are often treated with both.
How serious is the interaction between Hydroxychloroquine and Voclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during co-therapy. Correct potassium and magnesium abnormalities and avoid other QT-prolonging drugs.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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