Drug interactions
Hydroxychloroquine + Ziprasidone
Severity: Major
Hydroxychloroquine and Ziprasidone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone carries a notable QT-prolonging liability, and hydroxychloroquine adds to it. Together they increase the risk of life-threatening ventricular arrhythmias such as torsades de pointes.
What this interaction means in plain words
Hydroxychloroquine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxychloroquine belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive hERG potassium channel blockade producing QTc prolongation.
What to do
Avoid the combination and choose an antipsychotic with less QT effect if hydroxychloroquine is required. If it cannot be avoided, monitor ECG and electrolytes closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Hydroxychloroquine with Ziprasidone?
MediHelp rates the interaction as major. Hydroxychloroquine and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone carries a notable QT-prolonging liability, and hydroxychloroquine adds to it. Together they increase the risk of life-threatening ventricular arrhythmias such as torsades de pointes.
How serious is the interaction between Hydroxychloroquine and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antipsychotic with less QT effect if hydroxychloroquine is required. If it cannot be avoided, monitor ECG and electrolytes closely.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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