Drug interactions
Hydroxyurea + Lomustine
Severity: Moderate
Hydroxyurea and Lomustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents suppress bone marrow function, so giving them together can deepen and prolong neutropenia, thrombocytopenia and anemia. Lomustine in particular causes delayed and cumulative myelosuppression, which makes the overlap hard to predict.
What this interaction means in plain words
Hydroxyurea and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyurea belongs to Miscellaneous; Lomustine belongs to Oncology.
Why it happens
Additive pharmacodynamic myelosuppression from two cytotoxic agents acting through different mechanisms.
What to do
Monitor complete blood counts regularly, including the delayed nadir after lomustine. Reduce doses or delay cycles if counts fall below the thresholds for retreatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lomustine
- Adenovirus types 4 and 7 live + Lomustine Contraindicated
- Bcg vaccine live + Lomustine Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Lomustine Contraindicated
- Lomustine + Measles mumps and rubella vaccine Contraindicated
- Lomustine + Measles mumps and rubella vaccine live Contraindicated
- Lomustine + Measles mumps rubella and varicella vaccine live Contraindicated
Other interactions of Hydroxyurea
Frequently asked questions
Can I take Hydroxyurea with Lomustine?
MediHelp rates the interaction as moderate. Hydroxyurea and Lomustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents suppress bone marrow function, so giving them together can deepen and prolong neutropenia, thrombocytopenia and anemia. Lomustine in particular causes delayed and cumulative myelosuppression, which makes the overlap hard to predict.
How serious is the interaction between Hydroxyurea and Lomustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, including the delayed nadir after lomustine. Reduce doses or delay cycles if counts fall below the thresholds for retreatment.
What other medicines interact with Lomustine?
MediHelp also lists interactions of Lomustine with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Lomustine page.
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