Drug interactions
Hydroxyzine + Lurasidone
Severity: Moderate
Hydroxyzine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so taking them together can produce greater drowsiness, impaired psychomotor performance and dizziness. Hydroxyzine also has a QT-prolonging potential, which adds modest cardiac concern in vulnerable patients.
What this interaction means in plain words
Hydroxyzine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Lurasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antihistaminic and antipsychotic effects, with possible additive QT effects.
What to do
Start with the lowest hydroxyzine dose and monitor for excess sedation and falls, particularly in older adults. Check ECG and electrolytes if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Lurasidone?
MediHelp rates the interaction as moderate. Hydroxyzine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so taking them together can produce greater drowsiness, impaired psychomotor performance and dizziness. Hydroxyzine also has a QT-prolonging potential, which adds modest cardiac concern in vulnerable patients.
How serious is the interaction between Hydroxyzine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest hydroxyzine dose and monitor for excess sedation and falls, particularly in older adults. Check ECG and electrolytes if other QT-prolonging risk factors are present.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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