Drug interactions
Hydroxyzine + Macimorelin
Severity: Major
Hydroxyzine and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes QT prolongation, and hydroxyzine adds to this effect, which raises the risk of serious ventricular arrhythmias during the diagnostic test. Interpretation is also not affected by this, but safety is.
What this interaction means in plain words
Hydroxyzine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyzine belongs to Respiratory; Macimorelin belongs to Endocrine.
Why it happens
Additive prolongation of cardiac repolarization (QT interval).
What to do
Avoid giving hydroxyzine around the time of the macimorelin test, and consider delaying the test until hydroxyzine has been cleared. If unavoidable, obtain an ECG and correct electrolytes first.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Macimorelin
Frequently asked questions
Can I take Hydroxyzine with Macimorelin?
MediHelp rates the interaction as major. Hydroxyzine and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin causes QT prolongation, and hydroxyzine adds to this effect, which raises the risk of serious ventricular arrhythmias during the diagnostic test. Interpretation is also not affected by this, but safety is.
How serious is the interaction between Hydroxyzine and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving hydroxyzine around the time of the macimorelin test, and consider delaying the test until hydroxyzine has been cleared. If unavoidable, obtain an ECG and correct electrolytes first.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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