Drug interactions
Hydroxyzine + Nabilone
Severity: Moderate
Hydroxyzine and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine, and with nabilone it can cause excessive drowsiness and slowed reactions. Anticholinergic effects such as confusion and dry mouth may also be additive.
What this interaction means in plain words
Hydroxyzine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from cannabinoid agonism and H1-antihistamine activity, plus additive anticholinergic effects.
What to do
Monitor for oversedation and confusion, and reduce doses in older patients. Advise against driving or operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Nabilone?
MediHelp rates the interaction as moderate. Hydroxyzine and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine, and with nabilone it can cause excessive drowsiness and slowed reactions. Anticholinergic effects such as confusion and dry mouth may also be additive.
How serious is the interaction between Hydroxyzine and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and confusion, and reduce doses in older patients. Advise against driving or operating machinery.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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