Drug interactions
Hydroxyzine + Osilodrostat
Severity: Major
Hydroxyzine and Osilodrostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Their combination may increase the risk of torsades de pointes, especially with hypokalemia or hypomagnesemia.
What this interaction means in plain words
Hydroxyzine and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyzine belongs to Respiratory; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT prolongation via cardiac potassium channel (hERG) effects.
What to do
Obtain baseline and follow-up ECG and correct potassium and magnesium; consider an alternative to hydroxyzine if QTc lengthens substantially.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Hydroxyzine with Osilodrostat?
MediHelp rates the interaction as major. Hydroxyzine and Osilodrostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval. Their combination may increase the risk of torsades de pointes, especially with hypokalemia or hypomagnesemia.
How serious is the interaction between Hydroxyzine and Osilodrostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECG and correct potassium and magnesium; consider an alternative to hydroxyzine if QTc lengthens substantially.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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