Drug interactions
Hydroxyzine + Osimertinib
Severity: Major
Hydroxyzine and Osimertinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and hydroxyzine adds to this effect. The combination may raise the risk of torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Hydroxyzine and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyzine belongs to Respiratory; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation through delayed cardiac repolarization.
What to do
Prefer an antihistamine or anxiolytic without QT effects. If combined, monitor ECG and electrolytes periodically.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Hydroxyzine with Osimertinib?
MediHelp rates the interaction as major. Hydroxyzine and Osimertinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Osimertinib can prolong the QTc interval, and hydroxyzine adds to this effect. The combination may raise the risk of torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Hydroxyzine and Osimertinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antihistamine or anxiolytic without QT effects. If combined, monitor ECG and electrolytes periodically.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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