Drug interactions
Hydroxyzine + Oxaliplatin
Severity: Moderate
Hydroxyzine and Oxaliplatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is associated with QT prolongation and torsades de pointes, and oxaliplatin may also lengthen the QT interval. Combined use may increase arrhythmia risk, especially in older patients or those with electrolyte disturbances.
What this interaction means in plain words
Hydroxyzine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Oxaliplatin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation; hydroxyzine blocks hERG potassium channels.
What to do
Use the lowest effective hydroxyzine dose for the shortest time, or choose a non-QT-prolonging antihistamine or antiemetic. Check ECG and electrolytes in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Oxaliplatin?
MediHelp rates the interaction as moderate. Hydroxyzine and Oxaliplatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is associated with QT prolongation and torsades de pointes, and oxaliplatin may also lengthen the QT interval. Combined use may increase arrhythmia risk, especially in older patients or those with electrolyte disturbances.
How serious is the interaction between Hydroxyzine and Oxaliplatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose for the shortest time, or choose a non-QT-prolonging antihistamine or antiemetic. Check ECG and electrolytes in patients with cardiac risk factors.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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