Drug interactions
Hydroxyzine + Paliperidone
Severity: Moderate
Hydroxyzine and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can prolong the QT interval and has been linked to torsades de pointes, and paliperidone adds to this risk. Additive sedation and anticholinergic effects may also occur.
What this interaction means in plain words
Hydroxyzine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Paliperidone belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus additive CNS depression.
What to do
Use the lowest effective hydroxyzine dose for the shortest time and consider a non-QT-prolonging alternative. Check ECG and electrolytes in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Paliperidone?
MediHelp rates the interaction as moderate. Hydroxyzine and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine can prolong the QT interval and has been linked to torsades de pointes, and paliperidone adds to this risk. Additive sedation and anticholinergic effects may also occur.
How serious is the interaction between Hydroxyzine and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective hydroxyzine dose for the shortest time and consider a non-QT-prolonging alternative. Check ECG and electrolytes in patients with cardiac risk factors.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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