Drug interactions
Hydroxyzine + Pentazocine
Severity: Moderate
Hydroxyzine and Pentazocine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine is a sedating antihistamine, and with an opioid it can produce excessive drowsiness, confusion and respiratory depression. Elderly patients are at greater risk of falls and delirium.
What this interaction means in plain words
Hydroxyzine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Pentazocine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid activity and central H1 antihistamine effects.
What to do
Reduce the dose of one or both agents if needed and monitor for oversedation and slowed breathing. Avoid combining with other sedatives and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Pentazocine?
MediHelp rates the interaction as moderate. Hydroxyzine and Pentazocine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine is a sedating antihistamine, and with an opioid it can produce excessive drowsiness, confusion and respiratory depression. Elderly patients are at greater risk of falls and delirium.
How serious is the interaction between Hydroxyzine and Pentazocine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the dose of one or both agents if needed and monitor for oversedation and slowed breathing. Avoid combining with other sedatives and alcohol.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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