Drug interactions
Hydroxyzine + Perphenazine
Severity: Major
Hydroxyzine and Perphenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and have QT-prolonging potential, so the combination increases drowsiness and may raise the risk of torsades de pointes. Additive anticholinergic effects may also cause confusion, particularly in older patients.
What this interaction means in plain words
Hydroxyzine and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Hydroxyzine belongs to Respiratory; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects and QTc prolongation.
What to do
Obtain a baseline ECG, correct electrolytes, and use the lowest effective doses. Avoid the combination in patients with long QT, heart disease or other QT-prolonging drugs, and in elderly patients.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Perphenazine?
MediHelp rates the interaction as major. Hydroxyzine and Perphenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause sedation and have QT-prolonging potential, so the combination increases drowsiness and may raise the risk of torsades de pointes. Additive anticholinergic effects may also cause confusion, particularly in older patients.
How serious is the interaction between Hydroxyzine and Perphenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG, correct electrolytes, and use the lowest effective doses. Avoid the combination in patients with long QT, heart disease or other QT-prolonging drugs, and in elderly patients.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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