Drug interactions
Hydroxyzine + Rilpivirine
Severity: Moderate
Hydroxyzine and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydroxyzine can prolong the QT interval, and rilpivirine at supratherapeutic doses has also been associated with QT prolongation. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
What this interaction means in plain words
Hydroxyzine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT prolongation via cardiac ion channel effects.
What to do
Obtain ECG and check electrolytes if other QT risk factors exist; consider an alternative to hydroxyzine if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Hydroxyzine with Rilpivirine?
MediHelp rates the interaction as moderate. Hydroxyzine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydroxyzine can prolong the QT interval, and rilpivirine at supratherapeutic doses has also been associated with QT prolongation. Combined use may add to arrhythmia risk, mainly in patients with other risk factors.
How serious is the interaction between Hydroxyzine and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain ECG and check electrolytes if other QT risk factors exist; consider an alternative to hydroxyzine if QTc is prolonged.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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