Drug interactions
Hydroxyzine + Solifenacin
Severity: Moderate
Hydroxyzine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly in patients with other risk factors. Both also have anticholinergic activity, so dry mouth, constipation, blurred vision, urinary retention and sedation or confusion may be amplified, especially in older adults.
What this interaction means in plain words
Hydroxyzine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation and additive antimuscarinic effects.
What to do
Avoid the combination in patients with congenital long QT, bradycardia, or electrolyte disturbances, and correct potassium and magnesium first. Consider a baseline ECG and monitor for anticholinergic effects, using the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Hydroxyzine with Solifenacin?
MediHelp rates the interaction as moderate. Hydroxyzine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may raise the risk of torsades de pointes, particularly in patients with other risk factors. Both also have anticholinergic activity, so dry mouth, constipation, blurred vision, urinary retention and sedation or confusion may be amplified, especially in older adults.
How serious is the interaction between Hydroxyzine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with congenital long QT, bradycardia, or electrolyte disturbances, and correct potassium and magnesium first. Consider a baseline ECG and monitor for anticholinergic effects, using the lowest effective doses.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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