Drug interactions
Hydroxyzine + Ziconotide
Severity: Moderate
Hydroxyzine and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziconotide can cause sedation, confusion and decreased alertness, and hydroxyzine may add to these effects. Cognitive impairment may be more pronounced with combined use.
What this interaction means in plain words
Hydroxyzine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hydroxyzine belongs to Respiratory; Ziconotide belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for cognitive impairment and sedation, and reduce or stop hydroxyzine if these occur. Review ziconotide dose if symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Hydroxyzine with Ziconotide?
MediHelp rates the interaction as moderate. Hydroxyzine and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziconotide can cause sedation, confusion and decreased alertness, and hydroxyzine may add to these effects. Cognitive impairment may be more pronounced with combined use.
How serious is the interaction between Hydroxyzine and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cognitive impairment and sedation, and reduce or stop hydroxyzine if these occur. Review ziconotide dose if symptoms persist.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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