Drug interactions
Hyoscyamine + Maprotiline
Severity: Moderate
Hyoscyamine and Maprotiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a potent antimuscarinic and maprotiline has anticholinergic activity. Together they can cause marked dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion.
What this interaction means in plain words
Hyoscyamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Maprotiline belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for signs of anticholinergic toxicity, especially in elderly patients and those with glaucoma, BPH or ileus risk. Reduce the dose or switch to a less anticholinergic option if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Maprotiline?
MediHelp rates the interaction as moderate. Hyoscyamine and Maprotiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a potent antimuscarinic and maprotiline has anticholinergic activity. Together they can cause marked dry mouth, constipation, urinary retention, tachycardia, blurred vision and confusion.
How serious is the interaction between Hyoscyamine and Maprotiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of anticholinergic toxicity, especially in elderly patients and those with glaucoma, BPH or ileus risk. Reduce the dose or switch to a less anticholinergic option if needed.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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