Drug interactions
Hyoscyamine + Pancuronium
Severity: Minor
Hyoscyamine and Pancuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is an antimuscarinic that adds to the vagolytic effect of pancuronium, which may increase heart rate. The effect is usually modest.
What this interaction means in plain words
Hyoscyamine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Hyoscyamine belongs to Genitourinary; Pancuronium belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic effects on cardiac vagal tone.
What to do
Monitor heart rate and ECG in patients with cardiac disease.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pancuronium
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Pancuronium?
MediHelp rates the interaction as minor. Hyoscyamine and Pancuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hyoscyamine is an antimuscarinic that adds to the vagolytic effect of pancuronium, which may increase heart rate. The effect is usually modest.
How serious is the interaction between Hyoscyamine and Pancuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG in patients with cardiac disease.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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