Drug interactions
Hyoscyamine + Ziprasidone
Severity: Moderate
Hyoscyamine and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine is a potent antimuscarinic and may add to the mild anticholinergic effects of ziprasidone. This increases the risk of constipation, urinary retention, dry mouth, tachycardia and confusion, especially in older adults.
What this interaction means in plain words
Hyoscyamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Hyoscyamine belongs to Genitourinary; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic toxicity such as delirium, constipation and urinary retention. Use the lowest effective hyoscyamine dose, and avoid the combination in frail elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Hyoscyamine with Ziprasidone?
MediHelp rates the interaction as moderate. Hyoscyamine and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine is a potent antimuscarinic and may add to the mild anticholinergic effects of ziprasidone. This increases the risk of constipation, urinary retention, dry mouth, tachycardia and confusion, especially in older adults.
How serious is the interaction between Hyoscyamine and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as delirium, constipation and urinary retention. Use the lowest effective hyoscyamine dose, and avoid the combination in frail elderly patients.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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