Drug interactions
Ibrutinib + Vilazodone
Severity: Moderate
Ibrutinib and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ibrutinib, which impairs platelet function, and serotonergic antidepressants, which reduce platelet serotonin uptake, can increase bleeding risk. Together they may raise the likelihood of bruising or clinically significant hemorrhage.
What this interaction means in plain words
Ibrutinib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ibrutinib belongs to Oncology; Vilazodone belongs to Central Nervous System.
Why it happens
Additive impairment of platelet function: ibrutinib inhibits platelet signalling and vilazodone depletes platelet serotonin.
What to do
Monitor for bruising, mucosal bleeding and gastrointestinal bleeding, and educate the patient on warning signs. Avoid adding other antiplatelet or anticoagulant drugs unless clearly needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Ibrutinib with Vilazodone?
MediHelp rates the interaction as moderate. Ibrutinib and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ibrutinib, which impairs platelet function, and serotonergic antidepressants, which reduce platelet serotonin uptake, can increase bleeding risk. Together they may raise the likelihood of bruising or clinically significant hemorrhage.
How serious is the interaction between Ibrutinib and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bruising, mucosal bleeding and gastrointestinal bleeding, and educate the patient on warning signs. Avoid adding other antiplatelet or anticoagulant drugs unless clearly needed.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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