Drug interactions
Ibuprofen + Ticlopidine
Severity: Major
Ibuprofen and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits platelet aggregation and ibuprofen impairs platelet function and irritates the gastric mucosa, so bleeding risk is increased. Ticlopidine may also modestly inhibit CYP2C9-mediated ibuprofen metabolism.
What this interaction means in plain words
Ibuprofen and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibuprofen belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive antiplatelet effects with NSAID gastric injury, plus possible minor CYP2C9 inhibition.
What to do
Avoid regular combination where possible; if used, add gastroprotection and monitor for bleeding signs and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Ibuprofen with Ticlopidine?
MediHelp rates the interaction as major. Ibuprofen and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits platelet aggregation and ibuprofen impairs platelet function and irritates the gastric mucosa, so bleeding risk is increased. Ticlopidine may also modestly inhibit CYP2C9-mediated ibuprofen metabolism.
How serious is the interaction between Ibuprofen and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular combination where possible; if used, add gastroprotection and monitor for bleeding signs and blood counts.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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