Drug interactions
Ibutilide + Indacaterol
Severity: Major
Ibutilide and Indacaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Beta-agonists can add to the risk by lowering potassium and causing tachycardia.
What this interaction means in plain words
Ibutilide and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Indacaterol belongs to Respiratory.
Why it happens
Additive prolongation of cardiac repolarization, aggravated by beta-agonist-induced hypokalemia.
What to do
Avoid giving indacaterol around ibutilide administration where possible. If both are needed, correct potassium and magnesium first and use continuous ECG monitoring.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Indacaterol?
MediHelp rates the interaction as major. Ibutilide and Indacaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide markedly prolongs the QT interval and carries a substantial risk of torsades de pointes. Beta-agonists can add to the risk by lowering potassium and causing tachycardia.
How serious is the interaction between Ibutilide and Indacaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving indacaterol around ibutilide administration where possible. If both are needed, correct potassium and magnesium first and use continuous ECG monitoring.
What other medicines interact with Indacaterol?
MediHelp also lists interactions of Indacaterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Indacaterol page.
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