Drug interactions
Ibutilide + Sevoflurane
Severity: Major
Ibutilide and Sevoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide is a class III antiarrhythmic with a substantial risk of torsades de pointes. Sevoflurane also prolongs QTc, increasing the likelihood of serious ventricular arrhythmia.
What this interaction means in plain words
Ibutilide and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ibutilide belongs to Cardiovascular; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive prolongation of ventricular repolarization through potassium channel effects.
What to do
Avoid giving ibutilide during sevoflurane anesthesia where possible and use another cardioversion or rate-control strategy. If unavoidable, correct electrolytes and use continuous ECG monitoring with defibrillation available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sevoflurane
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Sevoflurane?
MediHelp rates the interaction as major. Ibutilide and Sevoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide is a class III antiarrhythmic with a substantial risk of torsades de pointes. Sevoflurane also prolongs QTc, increasing the likelihood of serious ventricular arrhythmia.
How serious is the interaction between Ibutilide and Sevoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving ibutilide during sevoflurane anesthesia where possible and use another cardioversion or rate-control strategy. If unavoidable, correct electrolytes and use continuous ECG monitoring with defibrillation available.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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