Drug interactions
Ibutilide + Sotalol
Severity: Contraindicated
Ibutilide and Sotalol: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are class III antiarrhythmics that markedly prolong repolarization, and together they substantially raise the risk of torsades de pointes. Ibutilide labeling advises against giving it with other drugs that prolong QT, and class III agents are typically withheld before ibutilide use.
What this interaction means in plain words
Ibutilide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ibutilide belongs to Cardiovascular; Sotalol belongs to Cardiovascular.
Why it happens
Additive IKr potassium channel blockade causing marked QT prolongation.
What to do
Do not combine; hold sotalol before ibutilide cardioversion for an interval based on its half-life and renal function, as advised in labeling. Use an alternative cardioversion strategy if sotalol cannot be withheld.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Ibutilide with Sotalol?
MediHelp rates the interaction as contraindicated. Ibutilide and Sotalol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are class III antiarrhythmics that markedly prolong repolarization, and together they substantially raise the risk of torsades de pointes. Ibutilide labeling advises against giving it with other drugs that prolong QT, and class III agents are typically withheld before ibutilide use.
How serious is the interaction between Ibutilide and Sotalol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; hold sotalol before ibutilide cardioversion for an interval based on its half-life and renal function, as advised in labeling. Use an alternative cardioversion strategy if sotalol cannot be withheld.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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