Drug interactions
Icatibant + Perindopril
Severity: Minor
Icatibant and Perindopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Icatibant blocks bradykinin B2 receptors, and part of the effect of ACE inhibitors depends on raised bradykinin. Icatibant may therefore blunt the antihypertensive effect of perindopril, though the clinical significance is uncertain.
What this interaction means in plain words
Icatibant and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Icatibant belongs to Miscellaneous; Perindopril belongs to Cardiovascular.
Why it happens
Bradykinin B2 receptor antagonism may counteract the bradykinin-mediated component of ACE inhibitor action.
What to do
Monitor blood pressure around icatibant use. No dose change is usually needed for short-term treatment of attacks.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Icatibant and Perindopril, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Icatibant
Frequently asked questions
Can I take Icatibant with Perindopril?
MediHelp rates the interaction as minor. Icatibant and Perindopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icatibant blocks bradykinin B2 receptors, and part of the effect of ACE inhibitors depends on raised bradykinin. Icatibant may therefore blunt the antihypertensive effect of perindopril, though the clinical significance is uncertain.
How serious is the interaction between Icatibant and Perindopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure around icatibant use. No dose change is usually needed for short-term treatment of attacks.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
