Drug interactions
Idelalisib + Linagliptin-metformin
Severity: Minor
Idelalisib and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and inhibits P-gp, which may raise linagliptin exposure. Linagliptin has a wide safety margin, so the effect is usually tolerable.
What this interaction means in plain words
Idelalisib and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Linagliptin-metformin belongs to Endocrine.
Why it happens
Idelalisib inhibits CYP3A4 and P-gp, decreasing linagliptin clearance.
What to do
No empirical dose change is needed; monitor glycemic control and watch for adverse effects. Note idelalisib can itself cause hyperglycemia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Linagliptin-metformin?
MediHelp rates the interaction as minor. Idelalisib and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A inhibitor and inhibits P-gp, which may raise linagliptin exposure. Linagliptin has a wide safety margin, so the effect is usually tolerable.
How serious is the interaction between Idelalisib and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor glycemic control and watch for adverse effects. Note idelalisib can itself cause hyperglycemia.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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