Drug interactions
Idelalisib + Metaxalone
Severity: Moderate
Idelalisib and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may raise metaxalone concentrations, since CYP3A4 contributes to its metabolism. This could increase sedation, dizziness and other adverse effects.
What this interaction means in plain words
Idelalisib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Inhibition of CYP3A-mediated metabolism of metaxalone by idelalisib, increasing metaxalone exposure.
What to do
Monitor for excess drowsiness, and consider a lower metaxalone dose or a different muscle relaxant during idelalisib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Metaxalone?
MediHelp rates the interaction as moderate. Idelalisib and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may raise metaxalone concentrations, since CYP3A4 contributes to its metabolism. This could increase sedation, dizziness and other adverse effects.
How serious is the interaction between Idelalisib and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness, and consider a lower metaxalone dose or a different muscle relaxant during idelalisib therapy.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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