Drug interactions
Idelalisib + Paclitaxel
Severity: Major
Idelalisib and Paclitaxel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase paclitaxel exposure, since CYP3A4 and CYP2C8 both clear paclitaxel. Increased myelosuppression and neuropathy are possible.
What this interaction means in plain words
Idelalisib and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Paclitaxel belongs to Oncology.
Why it happens
Strong CYP3A inhibition reduces paclitaxel metabolism.
What to do
Avoid if an alternative is available; otherwise monitor blood counts and neuropathy and reduce paclitaxel dose for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paclitaxel
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Paclitaxel?
MediHelp rates the interaction as major. Idelalisib and Paclitaxel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor and may increase paclitaxel exposure, since CYP3A4 and CYP2C8 both clear paclitaxel. Increased myelosuppression and neuropathy are possible.
How serious is the interaction between Idelalisib and Paclitaxel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if an alternative is available; otherwise monitor blood counts and neuropathy and reduce paclitaxel dose for toxicity.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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