Drug interactions
Idelalisib + Primaquine
Severity: Moderate
Idelalisib and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase primaquine concentrations, which could increase dose-related adverse effects such as gastrointestinal upset and haemolysis or methaemoglobinaemia. The magnitude is uncertain because primaquine has other metabolic pathways.
What this interaction means in plain words
Idelalisib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4-mediated primaquine metabolism by idelalisib.
What to do
Monitor haemoglobin, methaemoglobin symptoms and gastrointestinal tolerance during coadministration. Consider an alternative if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Primaquine?
MediHelp rates the interaction as moderate. Idelalisib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase primaquine concentrations, which could increase dose-related adverse effects such as gastrointestinal upset and haemolysis or methaemoglobinaemia. The magnitude is uncertain because primaquine has other metabolic pathways.
How serious is the interaction between Idelalisib and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor haemoglobin, methaemoglobin symptoms and gastrointestinal tolerance during coadministration. Consider an alternative if toxicity appears.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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