Drug interactions
Idelalisib + Rifampicin
Severity: Major
Idelalisib and Rifampicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin markedly decreases idelalisib exposure, which may lead to loss of efficacy in hematologic malignancy.
What this interaction means in plain words
Idelalisib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Idelalisib belongs to Oncology; Rifampicin belongs to Anti Bacterial.
Why it happens
Strong CYP3A induction by rifampicin accelerates idelalisib metabolism.
What to do
Avoid the combination and use an alternative antimycobacterial if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Idelalisib with Rifampicin?
MediHelp rates the interaction as major. Idelalisib and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin markedly decreases idelalisib exposure, which may lead to loss of efficacy in hematologic malignancy.
How serious is the interaction between Idelalisib and Rifampicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antimycobacterial if possible.
What other medicines interact with Idelalisib?
MediHelp also lists interactions of Idelalisib with, for example, Alfuzosin, Cisapride, Dihydroergotamine. The full list is on the Idelalisib page.
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