Drug interactions
Idelalisib + Roflumilast
Severity: Moderate
Idelalisib and Roflumilast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A inhibitor and may increase exposure to roflumilast. This may increase its adverse effects such as diarrhea, weight loss, nausea and psychiatric events.
What this interaction means in plain words
Idelalisib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Roflumilast belongs to Respiratory.
Why it happens
Idelalisib inhibits CYP3A4, reducing roflumilast clearance.
What to do
Monitor for roflumilast adverse effects, including weight loss, mood changes and gastrointestinal symptoms, and consider interrupting roflumilast if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Idelalisib and Roflumilast, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Roflumilast
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Roflumilast?
MediHelp rates the interaction as moderate. Idelalisib and Roflumilast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A inhibitor and may increase exposure to roflumilast. This may increase its adverse effects such as diarrhea, weight loss, nausea and psychiatric events.
How serious is the interaction between Idelalisib and Roflumilast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for roflumilast adverse effects, including weight loss, mood changes and gastrointestinal symptoms, and consider interrupting roflumilast if they occur.
What other medicines interact with Roflumilast?
MediHelp also lists interactions of Roflumilast with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Roflumilast page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
