Drug interactions
Idelalisib + Terbinafine
Severity: Minor
Idelalisib and Terbinafine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and may modestly raise terbinafine concentrations. The clinical impact is expected to be limited.
What this interaction means in plain words
Idelalisib and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Terbinafine belongs to Anti Fungals.
Why it happens
Idelalisib inhibits CYP3A4, a minor pathway of terbinafine metabolism.
What to do
No routine adjustment is needed. Monitor for terbinafine adverse effects, particularly hepatic ones, since idelalisib is itself hepatotoxic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Terbinafine?
MediHelp rates the interaction as minor. Idelalisib and Terbinafine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A4 inhibitor and may modestly raise terbinafine concentrations. The clinical impact is expected to be limited.
How serious is the interaction between Idelalisib and Terbinafine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for terbinafine adverse effects, particularly hepatic ones, since idelalisib is itself hepatotoxic.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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