Drug interactions
Idelalisib + Tinidazole
Severity: Minor
Idelalisib and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and may increase tinidazole exposure. Tinidazole adverse effects could be more likely, though the effect is probably modest.
What this interaction means in plain words
Idelalisib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Idelalisib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 by idelalisib reduces tinidazole clearance.
What to do
No routine adjustment; monitor for tinidazole adverse effects, especially with long courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Tinidazole?
MediHelp rates the interaction as minor. Idelalisib and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Idelalisib is a strong CYP3A4 inhibitor and may increase tinidazole exposure. Tinidazole adverse effects could be more likely, though the effect is probably modest.
How serious is the interaction between Idelalisib and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for tinidazole adverse effects, especially with long courses.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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