Drug interactions
Idelalisib + Umeclidinium-vilanterol
Severity: Moderate
Idelalisib and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Idelalisib is a strong CYP3A4 inhibitor and may increase systemic exposure to vilanterol. This may enhance beta-agonist cardiovascular effects and hypokalemia.
What this interaction means in plain words
Idelalisib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Idelalisib belongs to Oncology; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Idelalisib inhibits CYP3A4-mediated vilanterol metabolism.
What to do
Monitor heart rate, ECG and potassium, and watch for tremor or palpitations. Consider an alternative inhaler if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Idelalisib
- Alfuzosin + Idelalisib Contraindicated
- Cisapride + Idelalisib Contraindicated
- Dihydroergotamine + Idelalisib Contraindicated
- Dronedarone + Idelalisib Contraindicated
- Eletriptan + Idelalisib Contraindicated
- Eplerenone + Idelalisib Contraindicated
Frequently asked questions
Can I take Idelalisib with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Idelalisib and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Idelalisib is a strong CYP3A4 inhibitor and may increase systemic exposure to vilanterol. This may enhance beta-agonist cardiovascular effects and hypokalemia.
How serious is the interaction between Idelalisib and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and potassium, and watch for tremor or palpitations. Consider an alternative inhaler if adverse effects appear.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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